Structure of PDB 8sr8 Chain A

Receptor sequence
>8sr8A (length=1353) Species: 946362 (Salpingoeca rosetta) [Search protein sequence]
MIRQSVAAKTLLIENEDGKGSTRMEVQDFMKRFHMHASEDDKTGSPSTAW
GTLRFPTKEATAPYLRLSVNDDPEDALLFVKAMLAQKYGETYDRPSLILS
VTGGARNFTLPPRLETAIAKGLRLAAQRTNAWVVTGGTNTGVMKLTGQIM
EALSKTQSHFIPPTIGIATYGVIIGGDDMTRGEPPKIGLEYEMHKKDPPK
TTPLDDNHNLFLLVDDGSTNKFGKEIKFRAAFENAAGQAFAAPVVTIVVQ
GGPGTLGTALQAVRQGTPIVVVDGSGLAADVLAYAYNFMHNPLTRFKSYT
IDDLRQKVAQTFNPKSSQQLTNLLDSALECVQDPNLVVVYSLQESGIDEF
DDCILKAIFSSQGKLGNKLKQAMYFDQLDVAKRALSEASKNGQHNEIAAC
INDNLMAAMMHNKPHFVELYLGFDAKIYELKPSEEVAKTNITALDELPSF
ALAIEELYKREAKKPHSHVQRLVSLSNTDVLGRHYRGRDLANTRAYNVLR
MDQIFARLVSKDFSVNRDFTIYDSKYDKVPGIQFRRTAQASHMLFLWAIC
LDRFRMARHFWLIGDQSIINALVASRILERLSTHRALQGPHLAEERAKMQ
HNAKKFEELAVGVLGECHGSDSHMASEMLHSKNDMFNKKNAINIAYDAKS
LAFLSHPATQSVINADWYGHLKSVTSFWAVLFAFFFPFFVLPFINFSGAH
RLRRKFAKFYSAPYTRFISDLLSHFVLCVVTSYFVLDKLEDTISAIEWIL
LVWFVALLLEELRQMIFCDGIAEYISDTWNRLDLIMITLFFVGFFTHASD
PSNQDSKVVSKGIHAFLVVVLWLRFMRYYALSKNLGPKLIMMMEMMKDVS
TFVFLLLIFLIGYGVAAQSLLSPDEDFSSRTFIGVLFRPYFQIYGELFLD
DLNSEANCLGDTPFTECSRETVRMVPFFLAVYILGSNVLLVNLLIAMFND
TYMKVQEAAEDLWRKQNYELCAEYKDRPFLPAPFILLAHVHMLFMRLLRL
CGVHTQEHEKIQDDETKRKITTFEELNTDKFLRRWERERQEMLEARVKMT
NDNVVQAMGMMDQLLEHMISFRFSLDQQAEWYVPPEEYPKSGGVKRYLID
ASMVPLSIMCPSYDPVEYTHPSVAAQPVWADPADPRKIKFNVKDEVNGKV
VDRTSCHPSGISIDSNTGRPINPWGRTGMTGRGLLGKWGVNQAADTVVTR
WKRSPDGSILERDGKKVLEFVAIQRQDNKMWAIPGGFVDNGEDVALTSGR
EFMEEALGMGSAESKDSLAALFSSGTIVARIYCEDPRNTDNAWVETTCVN
FHDESGRHAARLKLQGGDDAEHARWMMVHGGLNLFASHRTLLQHVTSALN
AYF
3D structure
PDB8sr8 Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution
ChainA
Resolution2.77 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CLR A L878 V898 F905 L789 V809 F816
BS02 CLR A R1012 P1015 F1016 R923 P926 F927
BS03 CLR A E1009 M1013 F1016 E920 M924 F927
BS04 CLR A L946 F976 Y979 L857 F887 Y890
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005261 monoatomic cation channel activity
GO:0005262 calcium channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
GO:0098655 monoatomic cation transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8sr8, PDBe:8sr8, PDBj:8sr8
PDBsum8sr8
PubMed38773335
UniProtF2UB89

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