Structure of PDB 8sr6 Chain A

Receptor sequence

>8sr6A (length=451) Species: 91891 (Legionella pneumophila subsp. pneumophila) [Search protein sequence]

NADEWIDTSKIMLDLHIDNMSSSDYIPSAIDRTDLVMVQSVHLLRKTGGR
GLFAREDIPKGTCIGIYTGEVYSEQEFEQYLKEHVGSDKSYAMYVGGRVI
DAARKGNLTRYINFSDSQDNAEFVETTLNRKKVAKVITTKNIKAGQQLLI
NYNTYEEQASRYYYFLNPGDGWLSAQEFYQTYQSQYRLEQMPYNLEGFDL
KAGDRVLMTQIGRIILANYSLAKEQELNASDIDLPFLKVGSDEKILDFDE
ADTFTPLMAACYLGQVENVKWLIEHGANIDQQQSHSGHCPLSLTLKGYSL
AKDTQKYIDIIQLLIKNQVNLLVHDRSDKTFLHNAALVLNNLDFQSVVKF
LIGQNPIDINEYFTYIDENDFDIVMHCYNNKLFDKALVLLAFYPDYFKRN
YMSDNEGHNQFNINAFRKAIKDFNSNERSILLMQLRESGLHLPEDLLEQL
G

3D structure

PDB

8sr6 Histone methyltransferase activity of the secreted Legionella pneumophila SET-domain effector RomA/LegAS4 depends on its ankyrin domain

Chain

Resolution

2.22 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	Y148 K170 A173 M174 Y175 F204 E206 Y233 N234 T235 Y236 E237 T445 Y446 I447 E449 D451 H489 F492 N493	Y67 K89 A92 M93 Y94 F123 E125 Y152 N153 T154 Y155 E156 T364 Y365 I366 E368 D370 H408 F411 N412
BS02	SAH	A	R131 S171 Y172 R191 N194 F195 Y233 Y244 Y245 L247	R50 S90 Y91 R110 N113 F114 Y152 Y163 Y164 L166

External links

PDB	RCSB:8sr6, PDBe:8sr6, PDBj:8sr6
PDBsum	8sr6
PubMed	37795993
UniProt	Q5ZUS4

[Back to BioLiP]