Structure of PDB 8sql Chain A

Receptor sequence
>8sqlA (length=1396) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
CKLCRSPEGFGPISFYGDFTQCFIDGVILNLSAIFMITFGIRDLVNLCKK
KHSGIKYRRNWIIVSRMALVLLEIAFVSLASLNISKEEAENFTIVSQYAS
TMLSLFVALALHWIEYDRSVVANTVLLFYWLFETFGNFAKLINILIRHTY
EGIWYSGQTGFILTLFQVITCASILLLEALPKKPLMPHTRRKPNPYDSAN
IFSRITFSWMSGLMKTGYEKYLVEADLYKLPRNFSSEELSQKLEKNWENE
LKQKSNPSLSWAICRTFGSKMLLAAFFKAIHDVLAFTQPQLLRILIKFVT
DYNSERQDPQKLPIVRGFLIAFAMFLVGFTQTSVLHQYFLNVFNTGMYIK
SALTALIYQKSLVLSNEASGLSSTGDIVNLMSVDVQKLQDLTQWLNLIWS
GPFQIIICLYSLYKLLGNSMWVGVIILVIMMPLNSFLMRIQKKLQKSQMK
YKDERTRVISEILNNIKSLKLYAWEKPYREKLEEVRNNKELKNLTKLGCY
MAVTSFQFNIVPFLVSCCTFAVFVYTEDRALTTDLVFPALTLFNLLSFPL
MIIPMVLNSFIEASVSIGRLFTFFTNEELQPDSVQRLPKVKNIGDVAINI
GDDATFLWQRKPEYKVALKNINFQAKKGNLTCIVGKVGSGKTALLSCMLG
DLFRVKGFATVHGSVAYVSQVPWIMNGTVKENILFGHRYDAEFYEKTIKA
CALTIDLAILMDGDKTLVGEKGISLSGGQKARLSLARAVYARADTYLLDD
PLAAVDEHVARHLIEHVLGPNGLLHTKTKVLATNKVSALSIADSIALLDN
GEITQQGTYDEITKDADSPLWKLLREQGKVKWNIYLEYAKACNPKSVCVF
ILFIVISMFLSVMGNVWLKHWSEVNSRYGSNPNAARYLAIYFALGIGSAL
ATLIQTIVLWVFCTIHASKYLHNLMTNSVLRAPMTFFETTPIGRILNRFS
NDIYKVDALLGRTFSQFFVNAVKVTFTITVICATTWQFIFIIIPLSVFYI
YYQQYYLRTSRELRRLDSITRSPIYSHFQETLGGLATVRGYSQQKRFSHI
NQCRIDNNMSAFYPSINANRWLAYRLELIGSIIILGAATLSVFRLKQGTL
TAGMVGLSLSYALQITQTLNWIVRMTVEVETNIVSVERIKEYADLKSEAP
LIVEGHRPPGDIKFNNYSTRYRPELDLVLKHINIHIKPNEKVGIVGRTGA
GKSSLTLALFRMIEASEGNIVIDNIAINEIGLYDLRHKLSIIPQDSQVFE
GTVRENIDPINQYTDEAIWRALELSHLKEHVLSMSNDGLDAQLTEGGGNL
SVGQRQLLCLARAMLVPSKILVLDEATAAVDVETDKVVQETIRTAFKDRT
ILTIAHRLNTIMDSDRIIVLDNGKVAEFDSPGQLLSDNKSLFYSLC
3D structure
PDB8sql Cleaved Ycf1p Monomer in the Beta Conformation
ChainA
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 7.2.2.2: ABC-type Cd(2+) transporter.
7.6.2.3: ABC-type glutathione-S-conjugate transporter.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R206 G714 H715 R716 R770 K805 H1153 C1157 R190 G686 H687 R688 R742 K777 H1049 C1053
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008551 P-type cadmium transporter activity
GO:0015127 bilirubin transmembrane transporter activity
GO:0015431 ABC-type glutathione S-conjugate transporter activity
GO:0015434 ABC-type cadmium transporter activity
GO:0016887 ATP hydrolysis activity
GO:0042626 ATPase-coupled transmembrane transporter activity
GO:0140359 ABC-type transporter activity
Biological Process
GO:0006749 glutathione metabolic process
GO:0010038 response to metal ion
GO:0015723 bilirubin transport
GO:0042144 vacuole fusion, non-autophagic
GO:0045454 cell redox homeostasis
GO:0046686 response to cadmium ion
GO:0055085 transmembrane transport
GO:0070574 cadmium ion transmembrane transport
Cellular Component
GO:0000329 fungal-type vacuole membrane
GO:0005773 vacuole
GO:0005774 vacuolar membrane
GO:0016020 membrane
GO:0045121 membrane raft

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8sql, PDBe:8sql, PDBj:8sql
PDBsum8sql
PubMed
UniProtP39109|YCFI_YEAST Metal resistance protein YCF1 (Gene Name=YCF1)

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