Structure of PDB 8sq0 Chain A

Receptor sequence
>8sq0A (length=1402) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
CKLCRSPEGFGPISFYGDFTQCFIDGVILNLSAIFMITFGIRDLVNLCKK
KHSGIKYRRNWIIVSRMALVLLEIAFVSLASLNISKEEAENFTIVSQYAS
TMLSLFVALALHWIEYDRSVVANTVLLFYWLFETFGNFAKLINILIRHTY
EGIWYSGQTGFILTLFQVITCASILLLEALPKKPLMPTRRKPNPYDSANI
FSRITFSWMSGLMKTGYEKYLVEADLYKLPRNFSSEELSQKLEKNWENEL
KQKSNPSLSWAICRTFGSKMLLAAFFKAIHDVLAFTQPQLLRILIKFVTD
YNSERQDDHHPQKLPIVRGFLIAFAMFLVGFTQTSVLHQYFLNVFNTGMY
IKSALTALIYQKSLVLSNEASGLSSTGDIVNLMSVDVQKLQDLTQWLNLI
WSGPFQIIICLYSLYKLLGNSMWVGVIILVIMMPLNSFLMRIQKKLQKSQ
MKYKDERTRVISEILNNIKSLKLYAWEKPYREKLEEVRNNKELKNLTKLG
CYMAVTSFQFNIVPFLVSCCTFAVFVYTEDRALTTDLVFPALTLFNLLSF
PLMIIPMVLNSFIEASVSIGRLFTFFTNEELQPDSVQRLPKVKNIGDVAI
NIGDDATFLWQRKPEYKVALKNINFQAKKGNLTCIVGKVGSGKTALLSCM
LGDLFRVKGFATVHGSVAYVSQVPWIMNGTVKENILFGHRYDAEFYEKTI
KACALTIDLAILMDGDKTLVGEKGISLSGGQKARLSLARAVYARADTYLL
DDPLAAVDEHVARHLIEHVLGPNGLLHTKTKVLATNKVSALSIADSIALL
DNGEITQQGTYDEITKDADSPLWKLLEHREQGKVKWNIYLEYAKACNPKS
VCVFILFIVISMFLSVMGNVWLKHWSEVNSRYGSNPNAARYLAIYFALGI
GSALATLIQTIVLWVFCTIHASKYLHNLMTNSVLRAPMTFFETTPIGRIL
NRFSNDIYKVDALLGRTFSQFFVNAVKVTFTITVICATTWQFIFIIIPLS
VFYIYYQQYYLRTSRELRRLDSITRSPIYSHFQETLGGLATVRGYSQQKR
FSHINQCRIDNNMSAFYPSINANRWLAYRLELIGSIIILGAATLSVFRLK
QGTLTAGMVGLSLSYALQITQTLNWIVRMTVEVETNIVSVERIKEYADLK
SEAPLIVEGHRPQGDIKFNNYSTRYRPELDLVLKHINIHIKPNEKVGIVG
RTGAGKSSLTLALFRMIEASEGNIVIDNIAINEIGLYDLRHKLSIIPQDS
QVFEGTVRENIDPINQYTDEAIWRALELSHLKEHVLSMSNDGLDAQLTEG
GGNLSVGQRQLLCLARAMLVPSKILVLDEATAAVDVETDKVVQETIRTAF
KDRTILTIAHRLNTIMDSDRIIVLDNGKVAEFDSPGQLLSDNKSLFYSLC
ME
3D structure
PDB8sq0 Structure of a dimeric ABC transporter
ChainA
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 7.2.2.2: ABC-type Cd(2+) transporter.
7.6.2.3: ABC-type glutathione-S-conjugate transporter.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A G714 H715 R716 A769 R770 C1157 R1158 G688 H689 R690 A743 R744 C1057 R1058
BS02 GP7 A V934 W936 V951 F1068 F1072 I1096 L1099 Q1108 I1226 V834 W836 V851 F968 F972 I996 L999 Q1008 I1126
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008551 P-type cadmium transporter activity
GO:0015127 bilirubin transmembrane transporter activity
GO:0015431 ABC-type glutathione S-conjugate transporter activity
GO:0015434 ABC-type cadmium transporter activity
GO:0016887 ATP hydrolysis activity
GO:0042626 ATPase-coupled transmembrane transporter activity
GO:0140359 ABC-type transporter activity
Biological Process
GO:0006749 glutathione metabolic process
GO:0010038 response to metal ion
GO:0015723 bilirubin transport
GO:0042144 vacuole fusion, non-autophagic
GO:0045454 cell redox homeostasis
GO:0046686 response to cadmium ion
GO:0055085 transmembrane transport
GO:0070574 cadmium ion transmembrane transport
Cellular Component
GO:0000329 fungal-type vacuole membrane
GO:0005773 vacuole
GO:0005774 vacuolar membrane
GO:0016020 membrane
GO:0045121 membrane raft

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8sq0, PDBe:8sq0, PDBj:8sq0
PDBsum8sq0
PubMed
UniProtP39109|YCFI_YEAST Metal resistance protein YCF1 (Gene Name=YCF1)

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