Structure of PDB 8sod Chain A

Receptor sequence
>8sodA (length=941) Species: 9823 (Sus scrofa) [Search protein sequence]
LIPIEFVLPTSTPETALLHVAGHGNVEQMKAQVWLRALETSVSADFYHRL
GPDHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKVLHRSPGQIHVVQRH
APSEETLAFQRQLNALIGYDVTDVSNVHDDELEFTRRRLVTPRMAEVAGR
DPKLYAMHPWVTSKPLPEYLLKKITNNCVFIVIHRSTTSQTIKVSADDTP
GTILQSFFTKMAKKKSLMDIPESQNERDFVLRVCGRDEYLVGETPIKNFQ
WVRQCLKNGEEIHLVLDTPPDPALDEVRKEEWPLVGYHEQLTIHGKDHES
VFTVSLWDCDRKFRVKIRGIDIPVLPLTVFVEANIQYGQQVLCQRRTSPK
PFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGAQLLYYVNLLLIDHRF
LLRHGEYVLHMWQLNADKLTSATNPDKENSMSISILLDNYCHPIALPKHR
PTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESL
KDPKAYPKLFSSVKWGQQEIVAKTYQLLAKREVWDQSALDVGLTMQLLDC
NFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLK
RGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFT
QQVQVIDMLQKVTIDIKSLSSQVISQLKQKLENLQNLNLPQSFRVPYDPG
LKAGALVIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQ
DMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAK
IQQEVLSHWLKEKCPIEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDN
IMISNLFHIDFGVPFVLTPDFLFVMTSLHFQKFQDVCVKAYLALRHHTNL
LIILFSMMLMTGMPEDIEYIRDALTEEDAKKYFLDQIEVCR
3D structure
PDB8sod Structural and mechanistic basis for Gbetagamma mediated activation of phosphoinositide 3 kinase gamma
ChainA
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
2.7.1.137: phosphatidylinositol 3-kinase.
2.7.1.153: phosphatidylinositol-4,5-bisphosphate 3-kinase.
2.7.1.154: phosphatidylinositol-4-phosphate 3-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A M804 S806 I831 K833 Y867 I879 E880 I881 V882 T887 K890 M953 I963 D964 M714 S716 I741 K743 Y777 I789 E790 I791 V792 T797 K800 M852 I859 D860
Gene Ontology
Molecular Function
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016303 1-phosphatidylinositol-3-kinase activity
GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity
GO:0044024 histone H2AS1 kinase activity
GO:0046934 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0106310 protein serine kinase activity
Biological Process
GO:0001525 angiogenesis
GO:0002376 immune system process
GO:0006338 chromatin remodeling
GO:0006629 lipid metabolic process
GO:0006897 endocytosis
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
GO:0016310 phosphorylation
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process
GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO:0046854 phosphatidylinositol phosphate biosynthetic process
GO:0048015 phosphatidylinositol-mediated signaling
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005943 phosphatidylinositol 3-kinase complex, class IA
GO:0005944 phosphatidylinositol 3-kinase complex, class IB

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8sod, PDBe:8sod, PDBj:8sod
PDBsum8sod
PubMed38565696
UniProtO02697|PK3CG_PIG Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Gene Name=PIK3CG)

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