Structure of PDB 8snl Chain A

Receptor sequence
>8snlA (length=656) Species: 9606 (Homo sapiens) [Search protein sequence]
PHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKR
HFKLYLTSSTERFSQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRV
LAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSR
LQSPKVCGYLKVDNEELLPKGLVDREDPMKNTCKLLVVADHRFYRYMGRG
EESTTTNYLIELIDRVDDIYRNTSWDNAGFKGYGIQIEQIRILKSPQEVK
PGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQD
FDMGTLGLAYVGSPRANSHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGK
TILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSG
DHENNKMFSNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPG
IMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINATC
KGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCA
CNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPCTVGFCDMNGKCE
KRVQDVIERFWDFIDQLSINTFGKFLADNIVGSVLVFSLIFWIPFSILVH
CVDKKL
3D structure
PDB8snl Structure of human ADAM17/iRhom2 sheddase complex
ChainA
Resolution2.78 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.24.86: ADAM 17 endopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H405 H409 H415 H363 H367 H373
BS02 CA A V477 N480 R482 D484 E487 D490 V435 N438 R440 D442 E445 D448
External links
PDB RCSB:8snl, PDBe:8snl, PDBj:8snl
PDBsum8snl
PubMed
UniProtP78536|ADA17_HUMAN Disintegrin and metalloproteinase domain-containing protein 17 (Gene Name=ADAM17)

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