Structure of PDB 8smp Chain A

Receptor sequence
>8smpA (length=527) Species: 8355 (Xenopus laevis) [Search protein sequence]
IPKDLEPKHPTLWRIIYYSFGVVLLATITAAYVAEFQVILFSLGLYGLAM
LLHLMMQSLFAFLEIRRVNKSELPCSFKKTVALTIAGYQENPEYLIKCLE
SCKYVKYPKDKLKIILVIDGNTEDDAYMMEMFKDVFHGEDVGTYVWKGNY
HTEGINMVEELVRNKRCVCIMQQWGGKREVMYTAFQAIGTSVDYVQVCDS
DTKLDELATVEMVKVLESNDMYGAVGGDVRILNPYDSFISFMSSLRYWMA
FNVERACQSYFDCVSCISGPLGMYRNNILQVFLEAWYRQKFLGTYCTLGD
DRHLTNRVLSMGYRTKYTHKSRAFSETPSLYLRWLNQQTRWTKSYFREWL
YNAQWWHKHHIWMTYESVVSFIFPFFITATVIRLIYAGTIWNVVWLLLCI
QIMSLFKSIYACWLRGNFIMLLMSLYSMLYMTGLLPSKYFALLTLNKTGW
GTSGRKKIVGNYMPILPLSIWAAVLCGGVGYSIYMDCQNDWSTPEKQKEM
YHLLYGCVGYVMYWVIMAVMYWVWVKR
3D structure
PDB8smp Atomistic insights into hyaluronan synthesis, secretion, and length control
ChainA
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.1.212: hyaluronan synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UDP A Y107 E109 K218 D240 S241 R381 W491 R496 Y88 E90 K177 D199 S200 R340 W450 R455
Gene Ontology
Molecular Function
GO:0016757 glycosyltransferase activity
GO:0050501 hyaluronan synthase activity
Biological Process
GO:0030213 hyaluronan biosynthetic process
GO:0045226 extracellular polysaccharide biosynthetic process
GO:0085029 extracellular matrix assembly
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8smp, PDBe:8smp, PDBj:8smp
PDBsum8smp
PubMed
UniProtP13563|HYAS1_XENLA Hyaluronan synthase 1 (Gene Name=has1)

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