Structure of PDB 8smn Chain A

Receptor sequence
>8smnA (length=519) Species: 8355 (Xenopus laevis) [Search protein sequence]
IPKDLEPKHPTLWRIIYYSFGVVLLATITAAYVAEFQVLKHEAILFSLGL
YGLAMLLHLMMQSLFAFLEIRRVNKSELPCSFKKTVALTIAGYQENPEYL
IKCLESCKYVKYPKDKLKIILVIDGNTEDDAYMMEMFKDVFHGEDVGTYV
WKGNYHTEGINMVEELVRNKRCVCIMQQWGGKREVMYTAFQAIGTSVDYV
QVCDSDTKLDELATVEMVKVLESNDMYGAVGGDVRILNPYDSFISFMSSL
RYWMAFNVERACQSYFDCVSCISGPLGMYRNNILQVFLEAWYRQKFLGTY
CTLGDDRHLTNRVLSMGYRTKYTHKSRAFSETPSLYLRWLNQQTRWTKSY
FREWLYNAQWWHKHHIWMTYESVVSFIFPFFITATVIRLIYAGTIWNVVW
LLLCIQIMSLFKSIYACWLRGNFIMLLMSLYSMLYMTGLLPSKYFALLTL
NKNYMPILPLSIWAAVLCGGVGYSIYMDCQNDWSTPEKQKEMYHLLYGCV
GYVMYWVIMAVMYWVWVKR
3D structure
PDB8smn Atomistic insights into hyaluronan synthesis, secretion, and length control
ChainA
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.1.212: hyaluronan synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BDP A F60 S61 W436 F46 S47 W400
BS02 BDP A G66 I418 M444 G52 I382 M408
BS03 BDP A R287 R296 R251 R260
Gene Ontology
Molecular Function
GO:0016757 glycosyltransferase activity
GO:0050501 hyaluronan synthase activity
Biological Process
GO:0030213 hyaluronan biosynthetic process
GO:0045226 extracellular polysaccharide biosynthetic process
GO:0085029 extracellular matrix assembly
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8smn, PDBe:8smn, PDBj:8smn
PDBsum8smn
PubMed
UniProtP13563|HYAS1_XENLA Hyaluronan synthase 1 (Gene Name=has1)

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