Structure of PDB 8slx Chain A

Receptor sequence
>8slxA (length=594) Species: 10116 (Rattus norvegicus) [Search protein sequence]
FDRDRLFSVVSRGVPEELTGLLEYLRWNSKYLTDSAYTEGSTGKTCLMKA
VLNLVNACIMPLLQIDKDSGNPKLLVNAQCTDEFYQGHSALHIAIEKRSL
QCVKLLVENGADVHLRACGRFFQKHQGTCFYFGELPLSLAACTKQWDVVT
YLLENPHQPASLEATDSLGNTVLHALVMIADNSPENSALVIHMYDGLLQM
GARLCPTVQLEEISNHQGLTPLKLAAKEGKIEIFRHILQREFSGPYQPLS
RKFTEWCYGPVRVSLYDLSSVDSWEKNSVLEIIAFHCKSPNRHRMVVLEP
LNKLLQEKWDRLVSRFFFNFACYLVYMFIFTVVAYHQPSMLLLGHILILL
GGIYLLLGQLWYFWRRRLFIWISFMDSYFEILFLLQALLTVLSQVLRFME
TEWYLPLLVLSLVLGWLNLLYYTRGFQHTGIYSVMIQKVILRDLLRFLLV
YLVFLFGFAVALVSLSRYRSILDASLELFKFTIGMGELAFQEQLRFRGVV
LLLLLAYVLLTYVLLLNMLIALMSETVNHVADNSWSIWKLQKAISVLEME
NGYWWCRRKKHREGRLLKVGPDERWCFRVEEVNWAAWTLSEDPS
3D structure
PDB8slx Cannabidiol sensitizes TRPV2 channels to activation by 2-APB.
ChainA
Resolution3.23 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 P0T A L631 Y634 V635 L509 Y512 V513
BS02 P0T A L537 L541 M640 L444 L448 M518
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005261 monoatomic cation channel activity
GO:0005262 calcium channel activity
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0006915 apoptotic process
GO:0008285 negative regulation of cell population proliferation
GO:0009266 response to temperature stimulus
GO:0045773 positive regulation of axon extension
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
GO:0090280 positive regulation of calcium ion import
GO:0120162 positive regulation of cold-induced thermogenesis
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0012505 endomembrane system
GO:0016020 membrane
GO:0030027 lamellipodium
GO:0030424 axon
GO:0032584 growth cone membrane
GO:0042470 melanosome
GO:0044295 axonal growth cone
GO:0044297 cell body

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8slx, PDBe:8slx, PDBj:8slx
PDBsum8slx
PubMed37199723
UniProtQ9WUD2|TRPV2_RAT Transient receptor potential cation channel subfamily V member 2 (Gene Name=Trpv2)

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