Structure of PDB 8sl1 Chain A

Receptor sequence

>8sl1A (length=843) Species: 9606 (Homo sapiens)

GLPILYFSGRRERLLLRPEVLAEIPREAFTVEAWVKPEGGQNNPAIIAGV
FDNCSHTVSDKGWALGIRSGKDKGKRDARFFFSLCTDRVKKATILISHSR
YQPGTWTHVAATYDGRHMALYVDGTQVASSLDQSGPLNSPFMASCRSLLL
GGDSSEDGHYFRGHLGTLVFWSTALPQSHFQHSSQHSSGEEEATDLVLTA
SFEPVNTEWVPFRDEKYPRLEVLQGFEPEPEILSPLQPPLCGQTVCDNVE
LISQYNGYWPLRGEKVIRYQVVNICDDIVSEEQIRLQHEALNEAFSRYNI
SWQLSVHQVHNSTLRHRVVLVNCEPSKIGNDHCDPECEHPLTGTCFDPDS
PKRAYMSVKELKEALQLNSTHFLNIYFASSVREDLAGAATWPWDKDAVTH
LGGIVLSPAYYGMPGHTDTMIHQVGHVLGLYHVFKGVSERESCNDPCKET
VPSMETGDLCADTAPTPKSELCREPEPTTRFPGAPFTNYMSYTDDNCTDN
FTPNQVARMHCYLDLVYQQWTESRKPTPIPIPPMVIGQTNKSLTIHWLPP
ISGVVYDRASGSLCGACTEDGTFRQYVHTASSRRVCDSSGYWTPEEAVGP
PDVDQPCEPSLQAWSPEVHLYHMNMTVPCPTEGCSLELLFQHPVQADTLT
LWVTSFFMESSQVLFDTEILLENKESVHLGPLDTFCDIPLTIKLHVDGKV
SGVKVYTFDERIEIDAALLTSQPHSPLCSGCRPVRYQVLRDPPFASGLPV
VVTHSHRKFTDVEVTPGQMYQYQVLAEAGGELGEASPPLNHIHGAPYCGD
GKVSERLGEECDDGDLVSGDGCSKVCELEEGFNCVGEPSLCYM

3D structure

• PDB: 8sl1 Cryo-EM structure of human PAPP-A2 and mechanism of substrate recognition
• Chain: A
• Resolution: 3.13 Å

Enzymatic activity

• Enzyme Commision number: 3.4.24.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	A	H499 H503 H509	H422 H426 H432
BS02	CA	A	E679 D685 Q695 D798	E596 D602 Q612 D715
BS03	CA	A	Y880 C881 D883 K885 E892 D895	Y797 C798 D800 K802 E809 D812

Gene Ontology

Molecular Function

• GO:0008237 metallopeptidase activity

External links

• PDB: RCSB:8sl1, PDBe:8sl1, PDBj:8sl1
• PDBsum: 8sl1
• PubMed: 37898658
• UniProt: Q9BXP8|PAPP2_HUMAN Pappalysin-2 (Gene Name=PAPPA2)