Structure of PDB 8sj8 Chain A

Receptor sequence
>8sj8A (length=326) Species: 9606 (Homo sapiens) [Search protein sequence]
GASKLRAVLEKLKLSRDDISTAAGMVKGVVDHLLLRLKCDSAFRGVGLLK
ISAPNEFDVMFKLEVPRIQLEEYSNTRAYYFVKFPLSQFLEGEILSASKM
LSKFRKIIKEEIDVIMKPAVTLLISEKISVDITLALESKSSWPASTQEGL
RIQNWLSAKVRKQLRLKPFYLVPKHAEETWRLSFSHIEKEILNNHGKSKT
CCENKEEKCCRKDCLKLMKYLLEQLKERFKDKKHLDKFSSYHVKTAFFHV
CTQNPQDSQWDRKDLGLCFDNCVTYFLQCLRTEKLENYFIPEFNLFSSNL
IDKRSKEFLTKQIEYERNNEFPVFDE
3D structure
PDB8sj8 Structure of binary complex of human cGAS and bound ppp(2'-5')GpG
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.86: cyclic GMP-AMP synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H390 C396 C397 C404 H195 C201 C202 C209
BS02 OKR A D227 P306 D319 K362 H363 R376 S434 Y436 H437 D58 P118 D131 K174 H175 R181 S239 Y241 H242
External links
PDB RCSB:8sj8, PDBe:8sj8, PDBj:8sj8
PDBsum8sj8
PubMed38740774
UniProtQ8N884|CGAS_HUMAN Cyclic GMP-AMP synthase (Gene Name=CGAS)

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