Structure of PDB 8sj7 Chain A

Receptor sequence

>8sj7A (length=404) Species: 6239 (Caenorhabditis elegans) [Search protein sequence]

LPTWSLMRSRLSLSEVLDSGDLMKFAVDKTGCQFLEKAVKGSLTSYQKFQ
LFEQVIGRKDDFLKLSTNIFGNYLVQSVIGISLATNDDGYTKRQEKLKNF
ISSQMTDMCLDKFACRVIQSSLQNMDLSLACKLVQALPRDARLIAICVDQ
NANHVIQKVVAVIPLKNWEFIVDFVATPEHLRQICSDKYGCRVVQTIIEK
LTADSMNVDLTSAAQNLRERALQRLMTSVTNRCQELATNEYANYIIQHIV
SNDDLAVYRECIIEKCLMRNLLSLSQEKFASHVVEKAFLHAPLELLAEMM
DEIFDGYIPHPDTGKDALDIMMFHQFGNYVVQCMLTICCDAVSGRRQTKE
GGYDHAISFQDWLKKLHSRVTKERHRLSRFSSGKKMIETLANLRSTHSLM
LEPR

3D structure

PDB

8sj7 Competing intrinsically-disordered regions and electrostatic repulsion regulate PUF RNA-binding affinity

Chain

Resolution

2.09 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	N244 Y245 F285 R288 Q291 Q322 N323 H326 Q329 Y361 R364 Q367 Y413 N415 Y416 Q419 K450 S453 H454 E457 F495 N500 Y501 Q504 F552 S553 S554 K557	N72 Y73 F113 R116 Q119 Q150 N151 H154 Q157 Y189 R192 Q195 Y241 N243 Y244 Q247 K278 S281 H282 E285 F323 N328 Y329 Q332 F380 S381 S382 K385

Gene Ontology

	Molecular Function
GO:0003723	RNA binding

View graph for
Molecular Function

External links

PDB	RCSB:8sj7, PDBe:8sj7, PDBj:8sj7
PDBsum	8sj7
PubMed	37953271
UniProt	Q09312\|FBF2_CAEEL Fem-3 mRNA-binding factor 2 (Gene Name=fbf-2)

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