Structure of PDB 8sj2 Chain A

Receptor sequence

>8sj2A (length=355) Species: 10090 (Mus musculus) [Search protein sequence]

GPDKLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQL
NTGSYYEHVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKFNPLSHF
LEGEVLSATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLIRNP
EEISVDIILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLVPKN
AKDGNSFQGETWRLSFSHTEKYILNNHGIEKTCCESSGAKCCRKECLKLM
KYLLEQLKKEFQELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSCFDK
LLAFFLECLRTEKLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYERNNGF
PIFDK

3D structure

PDB

8sj2 Structure of ternary complex of cGAS with dsDNA and bound ATP and 2'-dGTP

Chain

Resolution

2.23 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.7.86: cyclic GMP-AMP synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	R158 L159 K160 R161 H203 E386 K395	R13 L14 K15 R16 H58 E235 K244
BS02	dna	A	R161 S165 N196 Y200 Y201 K372	R16 S20 N51 Y55 Y56 K221
BS03	dna	A	K335 T338	K184 T187
BS04	ATP	A	G198 S199 E211 D213 R364 S368 E371 K402 S420 Y421	G53 S54 E66 D68 R213 S217 E220 K251 S269 Y270
BS05	DGT	A	D213 G290 D307 I309 R364 S366 S368 C419	D68 G139 D156 I158 R213 S215 S217 C268
BS06	MG	A	E211 D213	E66 D68
BS07	ZN	A	H378 C385 C392	H227 C234 C241

External links

PDB	RCSB:8sj2, PDBe:8sj2, PDBj:8sj2
PDBsum	8sj2
PubMed	38740774
UniProt	Q8C6L5\|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)

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