Structure of PDB 8six Chain A

Receptor sequence
>8sixA (length=258) Species: 9606 (Homo sapiens) [Search protein sequence]
DWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMPENIKKEICILKMLN
HENVIKFYGHRREGNIQYLFMELASGGSLFDRIEPDIGMPEPDAQRFFHQ
LMAGVVYLHGIGITHRDIKPHNLLLDERDNLKIADYSLATVFRYNNRERL
LNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSD
SCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDR
WYNKPLKK
3D structure
PDB8six Discovery of MK-1468: A Potent, Kinome-Selective, Brain-Penetrant Amidoisoquinoline LRRK2 Inhibitor for the Potential Treatment of Parkinson's Disease.
ChainA
Resolution1.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZXP A L15 G16 E17 V23 A36 A87 G90 K132 H134 L137 L8 G9 E10 V16 A29 A74 G77 K119 H121 L124
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0000077 DNA damage checkpoint signaling
GO:0006468 protein phosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8six, PDBe:8six, PDBj:8six
PDBsum8six
PubMed37861679
UniProtO14757|CHK1_HUMAN Serine/threonine-protein kinase Chk1 (Gene Name=CHEK1)

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