Structure of PDB 8si0 Chain A

Receptor sequence
>8si0A (length=339) Species: 9606 (Homo sapiens) [Search protein sequence]
GASKLRAVLEKLKLSRDDISTAAGMVKGVVDHLLLRLKCDSAFRGVGLLN
VKISAPNEFDVMFKLEVPRIQLEEYSNTRAYYFVKFLSQFLEGEILSASK
MLSKFRKIIKEEINDIKDTDVIMKRKRGGSPAVTLLISEKISVDITLALE
SKSSWPASTQEGLRIQNWLSAKVRKQLRLKPFYLVPKHAEETWRLSFSHI
EKEILNNHGKSKTCCENKEEKCCRKDCLKLMKYLLEQLKERFKDKKHLDK
FSSYHVKTAFFHVCTQNPQDSQWDRKDLGLCFDNCVTYFLQCLRTEKLEN
YFIPEFNLFSSNLIDKRSKEFLTKQIEYERNNEFPVFDE
3D structure
PDB8si0 Structure of binary complex of human cGAS and bound cGAMP
ChainA
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.86: cyclic GMP-AMP synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1SY A R302 S305 P306 D319 K362 R376 S434 Y436 R127 S130 P131 D144 K187 R194 S252 Y254
BS02 ZN A H390 C396 C397 C404 H208 C214 C215 C222
External links
PDB RCSB:8si0, PDBe:8si0, PDBj:8si0
PDBsum8si0
PubMed38740774
UniProtQ8N884|CGAS_HUMAN Cyclic GMP-AMP synthase (Gene Name=CGAS)

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