Structure of PDB 8shz Chain A

Receptor sequence
>8shzA (length=334) Species: 9606 (Homo sapiens) [Search protein sequence]
ASKLRAVLEKLKLSRDDISTAAGMVKGVVDHLLLRLKCDSAFRGVGLLNT
GEHVKIPNEFDVMFKLEVPRIQLEEYSNTRAYYFVKFNPLSQFLEGEILS
ASKMLSKFRKIIKEEINDIKDTDVIMKPAVTLLISEKISVDITLALESKS
SWPASTQEGLRIQNWLSAKVRKQLRLKPFYLVPKQEETWRLSFSHIEKEI
LNNHGKSKTCCENKEEKCCRKDCLKLMKYLLEQLKERFKDKKHLDKFSSY
HVKTAFFHVCTQNPQDSQWDRKDLGLCFDNCVTYFLQCLRTEKLENYFIP
EFNLFSSNLIDKRSKEFLTKQIEYERNNEFPVFD
3D structure
PDB8shz Structure of human cGAS
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.86: cyclic GMP-AMP synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H390 C396 C397 C404 H204 C210 C211 C218
External links
PDB RCSB:8shz, PDBe:8shz, PDBj:8shz
PDBsum8shz
PubMed38740774
UniProtQ8N884|CGAS_HUMAN Cyclic GMP-AMP synthase (Gene Name=CGAS)

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