Structure of PDB 8shr Chain A

Receptor sequence
>8shrA (length=311) Species: 9606 (Homo sapiens) [Search protein sequence]
YFSSYGHYGIHEEMLKDKIRTESYRDFIYQNPHIFKDKVVLDVGCGTGIL
SMFAAKAGAKKVLGVDQSEILYQAMDIIRLNKLEDTITLIKGKIEEVHLP
VEKVDVIISEWMGYFLLFESMLDSVLYAKNKYLAKGGSVYPDICTISLVA
VSDVNKHADRIAFWDDVYGFKMSCMKKAVIPEAVVEVLDPKTLISEPCGI
KHIDCHTTSISDLEFSSDFTLKITRTSMCTAIAGYFDIYFEKNCHNRVVF
STGPQSTKTHWKQTVFLLEKPFSVKAGEALKGKVTVHKNKKDPRSLTVTL
TLNNSTQTYGL
3D structure
PDB8shr Crystal Structure of PRMT3 with Compound YD1-214
ChainA
Resolution1.92 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.319: type I protein arginine methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HIY A Y224 M233 R239 Y243 G263 C264 I268 L269 D285 Q286 K312 I313 E314 M340 S343 Y5 M14 R20 Y24 G44 C45 I49 L50 D66 Q67 K93 I94 E95 M121 S124
Gene Ontology
Molecular Function
GO:0016274 protein-arginine N-methyltransferase activity
Biological Process
GO:0018216 peptidyl-arginine methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8shr, PDBe:8shr, PDBj:8shr
PDBsum8shr
PubMed
UniProtO60678|ANM3_HUMAN Protein arginine N-methyltransferase 3 (Gene Name=PRMT3)

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