Structure of PDB 8shh Chain A

Receptor sequence
>8shhA (length=323) Species: 47853 (Micromonospora carbonacea) [Search protein sequence]
RGSVPRVFVAGGAGFIGSHYVRELVAGAYAGWQGCEVTVLDSLTYAGNLA
NLAGVRDAVTFVRGDICDGRLLAEVLPGHDVVLNFAAETHVDRSIADSAE
FLRTNVQGVQSLMQACLTAGVPTIVQVSTDEVYGSIEAGSWSEDAPLAPN
SPYAAAKAGGDLIALAYARTYGLPVRITRCGNNYGPYQFPEKVIPLFLTR
LMDGRSVPLYGDGRNVRDWIHVADHCRGIQTVVERGASGEVYHIAGTAEL
TNLELTQHLLDAVGGSWDAVERVPDHDRRYSLSDAKLRALGYAPRVPFAD
GLAETVAWYRANRHWWEPLRKQL
3D structure
PDB8shh EvdS6 is a bifunctional decarboxylase from the everninomicin gene cluster.
ChainA
Resolution1.93 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.2.1.46: dTDP-glucose 4,6-dehydratase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD A G11 F12 I13 D38 S39 L40 T41 G44 D62 I63 F82 A83 A84 T86 T101 V124 S125 T126 Y150 K154 C177 G14 F15 I16 D41 S42 L43 T44 G47 D65 I66 F85 A86 A87 T89 T104 V127 S128 T129 Y153 K157 C180
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0008460 dTDP-glucose 4,6-dehydratase activity
GO:0016829 lyase activity
Biological Process
GO:0009225 nucleotide-sugar metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8shh, PDBe:8shh, PDBj:8shh
PDBsum8shh
PubMed37286037
UniProtA0A1C5ADV9

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