Structure of PDB 8shb Chain A

Receptor sequence
>8shbA (length=302) Species: 9606 (Homo sapiens) [Search protein sequence]
GHYGIHEEMLKDKIRTESYRDFIYQNPHIFKDKVVLDVGCGTGILSMFAA
KAGAKKVLGVDQSEILYQAMDIIRLNKLEDTITLIKGKIEEVHLPVEKVD
VIISEWMGYFLLFESMLDSVLYAKNKYLAKGGSVYPDICTISLVAVSDVN
KHADRIAFWDDVYGFKMSCMKKAVIPEAVVEVLDPKTLISEPCGIKHIDC
HTTSISDLEFSSDFTLKITRTSMCTAIAGYFDIYFEKNCHNRVVFSTGPQ
STKTHWKQTVFLLEKPFSVKAGEALKGKVTVHKNSLTVTLTLNNSTQTYG
LQ
3D structure
PDB8shb Crystal Structure of PRMT3 with Compound YD1-208
ChainA
Resolution2.09 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.319: type I protein arginine methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GV3 A I229 H230 M233 G263 D285 Q286 K312 I313 E314 E329 W330 M331 Y333 M340 S343 H479 I5 H6 M9 G39 D61 Q62 K88 I89 E90 E105 W106 M107 Y109 M116 S119 H255
Gene Ontology
Molecular Function
GO:0016274 protein-arginine N-methyltransferase activity
Biological Process
GO:0018216 peptidyl-arginine methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8shb, PDBe:8shb, PDBj:8shb
PDBsum8shb
PubMed
UniProtO60678|ANM3_HUMAN Protein arginine N-methyltransferase 3 (Gene Name=PRMT3)

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