Structure of PDB 8sh8 Chain A

Receptor sequence
>8sh8A (length=169) Species: 2697049 (Severe acute respiratory syndrome coronavirus 2) [Search protein sequence]
SMVNSFSGYLKLTDNVYIKNADIVEEAKKVKPTVVVNAADVYLKHGGGVA
GALNKATNNAMQVESDDYIATNGPLKVGGSCVLSGHNLAKHCLHVVGPNV
NKGEDIQLLKSAYENFNQHEVLLAPLLSAGIFGADPIHSLRVCVDTVRTN
VYLAVFDKNLYDKLVSSFL
3D structure
PDB8sh8 Crystal structure of SARS-CoV-2 NSP3 macrodomain Asn40Asp mutant in complex with ADP-ribose (P43 crystal form)
ChainA
Resolution0.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.50: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AR6 A D22 I23 A38 G47 G48 V49 A50 L126 S128 A129 G130 I131 F132 A154 F156 D22 I23 A38 G47 G48 V49 A50 L126 S128 A129 G130 I131 F132 A154 F156
External links
PDB RCSB:8sh8, PDBe:8sh8, PDBj:8sh8
PDBsum8sh8
PubMed
UniProtP0DTD1|R1AB_SARS2 Replicase polyprotein 1ab (Gene Name=rep)

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