Structure of PDB 8sh1 Chain A

Receptor sequence

>8sh1A (length=293) Species: 9606 (Homo sapiens) [Search protein sequence]

ATNYIYTPLNQLKGGTIVNVYGVVKFFKPPYLSKGTDYCSVVTIVDQTNV
KLTCLLFSGNYEALPIIYKNGDIVRFHRLKIQVYKKETQGITSSGFASLT
FEGTLGAPIIPRTSSKYFNFTTEDHKMVEALRVWASTHMSPSWTLLKLCD
VQPMQYFDLTCQLLGKAEVDGASFLLKVWDGTRTPFPSWRVLIQDLVLEG
DLSHIHRLQNLTIDILVYDNHVHVARSLKVGSFLRIYSLHTKLQSMNSEN
QTMLSLEFHLHGGTSYGRGIRVLPESNSDVDQLKKDLESANLT

3D structure

PDB

8sh1 Human POT1 protects the telomeric ds-ss DNA junction by capping the 5' end of the chromosome.

Chain

Resolution

2.6 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	F31 K33 Y36 S38 K39 G40 D42 T48 L60 F62 Y89 Q94 S99 Y161 Y223 D224 S243 H266 G267 S270 Y271 R273	F26 K28 Y31 S33 K34 G35 D37 T43 L55 F57 Y84 Q89 S94 Y156 Y218 D219 S238 H261 G262 S265 Y266 R268
BS02	dna	A	Y9 H82 R83 A102 S120 K121 Y122	Y4 H77 R78 A97 S115 K116 Y117

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0043047	single-stranded telomeric DNA binding

	Biological Process
GO:0000723	telomere maintenance

	Cellular Component
GO:0000781	chromosome, telomeric region

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:8sh1, PDBe:8sh1, PDBj:8sh1
PDBsum	8sh1
PubMed	37590346
UniProt	Q9NUX5\|POTE1_HUMAN Protection of telomeres protein 1 (Gene Name=POT1)

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