Structure of PDB 8sge Chain A

Receptor sequence
>8sgeA (length=326) Species: 9606 (Homo sapiens) [Search protein sequence]
LACPAERSGHVAVSDGRHMFVWGGYKSNDFYLPREELWIYNMETGRWKKI
NTEGDVPPSMSGSCAVCVDRVLYLFGGHHSRGNTNKFYMLDSRSVLQWER
IDCQGIPPSSKDKLGVWVYKNKLIFFGGYGYLPEDKVLGTFEFDETSFWN
SSHPRGWNDHVHILDTETFTWSQPITTGKAPSPRAAHACATVGNRGFVFG
GRYRDARMNDLHYLNLDTWEWNELIPQGICPVGRSWHSLTPVSSDHLFLF
GGFTTDKQPLSDAWTYCISKNEWIQFNHPYTEKPRLWHTACASDEGEVIV
FGGCANNLLVHHRAAHSNEILIFSVQ
3D structure
PDB8sge Structure-based discovery and characterization of small molecule ligands and PROTAC degraders that co-opt the E3 ligase KLHDC2 for targeted protein degradation
ChainA
Resolution1.509 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZWS A K147 Y163 W191 R236 R241 S269 W270 L343 K113 Y129 W157 R202 R207 S235 W236 L309
External links
PDB RCSB:8sge, PDBe:8sge, PDBj:8sge
PDBsum8sge
PubMed38177675
UniProtQ9Y2U9|KLDC2_HUMAN Kelch domain-containing protein 2 (Gene Name=KLHDC2)

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