Structure of PDB 8sf3 Chain A

Receptor sequence
>8sf3A (length=662) Species: 5671 (Leishmania infantum) [Search protein sequence]
RDSNVVEPTEANGKKSHVGPHLGSRMRIYEYSIEHNDAFWAEIARRDFYW
KTTWPDDQHVKSYNFDKSKGPIFVKWFEGAVTNVCYNALDRHLPAHKDRV
CFYFEGNDPSVTEAVTYGSMYTRVVELANVLKYQYGIAKGDRVGLYLPMI
PFAAVAMLACARIGAVITVIFGGFSAQALSSRLKDAQTKLLITADASARG
TKPIPLKDVADEALKECEEEGMSIACLVAENMSCKMKEGRDTWYGDALAR
LTPEQHEECPVEWMDAEDVLFLLYTSGSTGKPKAIVHTTAGYMVYASTTF
MYSFDYHMDDVYFCTADIGWITGHSYVVYGPMIHCATSVLFEGVPNYPDY
SRWWQLVEKYKVSILYTAPTAIRSLMQAGDDYVKVGNRSTLRVLGSVGEP
INVEAWKWLRDVGGEGHCDVSDTWWQTETGGHMITPMPGCTPMKPGSATL
PFFGVQPVILDPMKLHEKQGPAEGLLAIRAPWPGMARTIYGDHARFEKTY
FGVDGYYMTGDGARRDSDGYYWITGRVDDVLNVSGHRIGTSEIEDAVNTH
PAVVESAVVGFPHNIKGEGIYVFLTFRQGTEVTPELLAAVKATVRKVIGP
LATPDVMQVARVGLPKTRSGKIVRRILRKVSAGQYTELGDTSTLANPDVV
EDLIAEHQRLCS
3D structure
PDB8sf3 Crystal Structure of Acetyl-coenzyme A synthetase from Leishmania infantum (AMP and CoA bound)
ChainA
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.2.1.1: acetate--CoA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AMP A G439 E440 P441 T464 W465 Q467 T468 D552 R567 R578 G398 E399 P400 T423 W424 Q426 T427 D511 R526 R537
BS02 COA A F209 G210 G211 R237 K240 R636 P641 F171 G172 G173 R199 K202 R595 P600
Gene Ontology
Molecular Function
GO:0003987 acetate-CoA ligase activity
GO:0005524 ATP binding
GO:0016208 AMP binding
GO:0016874 ligase activity
Biological Process
GO:0006085 acetyl-CoA biosynthetic process
GO:0019427 acetyl-CoA biosynthetic process from acetate

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Molecular Function
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Biological Process
External links
PDB RCSB:8sf3, PDBe:8sf3, PDBj:8sf3
PDBsum8sf3
PubMed
UniProtA4I093

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