Structure of PDB 8sdz Chain A

Receptor sequence
>8sdzA (length=500) Species: 10116 (Rattus norvegicus) [Search protein sequence]
AFNDLLKQVGGVGRFQLIQVTMVVAPLLLMASHNTLQNFTAAIPPHHCRP
PANANLGGLEAWLPLDKQGQPESCLRFTSPQRVTEPCIDGWVYDNSTFPS
TIVTEWNLVCSHRAFRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILN
YLQTAVSGTCAAYAPNYTVYCVFRLLSGMSLASIAINCMTLNVEWMPIHT
RAYVGTLIGYVYSLGQFLLAGIAYAVPHWRHLQLVVSVPFFIAFIYSWFF
IESARWYSSSGRLDLTLRALQRVARINGKQEEGAKLSIEVLRTSLQKELA
SAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDLQGFGVSMYLIQVIF
GAVDLPAKFVCFLVINSMGRRPAQMASLLLAGICILVNGIIPKSHTIIRT
SLAVLGKGCLASSFNCIFLYTGELYPTVIRQTGLGMGSTMARVGSIVSPL
VSMTAEFYPSMPLFIFGAVPVVASAVTALLPETLGQPLPDTVQDLKSRSR
3D structure
PDB8sdz The substrate and inhibitor binding mechanism of polyspecific transporter OAT1 revealed by high-resolution cryo-EM
ChainA
Resolution2.86 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 RTO A Y354 K382 F438 R466 S469 Y330 K358 F414 R442 S445
Gene Ontology
Molecular Function
GO:0005452 solute:inorganic anion antiporter activity
GO:0005515 protein binding
GO:0008514 organic anion transmembrane transporter activity
GO:0015132 prostaglandin transmembrane transporter activity
GO:0015139 alpha-ketoglutarate transmembrane transporter activity
GO:0015297 antiporter activity
GO:0015347 sodium-independent organic anion transmembrane transporter activity
GO:0022857 transmembrane transporter activity
GO:0031404 chloride ion binding
GO:0042802 identical protein binding
GO:0042910 xenobiotic transmembrane transporter activity
Biological Process
GO:0006820 monoatomic anion transport
GO:0014070 response to organic cyclic compound
GO:0015698 inorganic anion transport
GO:0015711 organic anion transport
GO:0015732 prostaglandin transport
GO:0015742 alpha-ketoglutarate transport
GO:0042908 xenobiotic transport
GO:0043252 sodium-independent organic anion transport
GO:0055085 transmembrane transport
GO:0072237 metanephric proximal tubule development
GO:0097254 renal tubular secretion
Cellular Component
GO:0005886 plasma membrane
GO:0005901 caveola
GO:0009925 basal plasma membrane
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8sdz, PDBe:8sdz, PDBj:8sdz
PDBsum8sdz
PubMed37845412
UniProtO35956|S22A6_RAT Solute carrier family 22 member 6 (Gene Name=Slc22a6)

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