Structure of PDB 8sds Chain A

Receptor sequence
>8sdsA (length=360) Species: 287 (Pseudomonas aeruginosa) [Search protein sequence]
APADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGR
RVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFD
GISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYS
NPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQ
GYGKDDRPLRVGPGPLDAEGHGVKTSAADLLRFVDANLHPERLDRPWAQA
LDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMALQPHRIARL
PAPQALEGQRLLNKTGSTNGFGAYVAFVPGRDLGLVILANRNYPNAERVK
IAYAILSGLE
3D structure
PDB8sds Natural Protein Engineering in the omega-Loop: The Role of Y221 in Ceftazidime and Ceftolozane Resistance in Pseudomonas-derived Cephalosporinase (PDC)
ChainA
Resolution1.63 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.2.6: beta-lactamase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CB4 A S64 Q120 Y151 N153 S319 N321 S62 Q118 Y149 N151 S317 N319
Gene Ontology
Molecular Function
GO:0008800 beta-lactamase activity
Biological Process
GO:0017001 antibiotic catabolic process
Cellular Component
GO:0030288 outer membrane-bounded periplasmic space

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8sds, PDBe:8sds, PDBj:8sds
PDBsum8sds
PubMed37850746
UniProtP24735|AMPC_PSEAE Beta-lactamase (Gene Name=ampC)

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