Structure of PDB 8scd Chain A

Receptor sequence
>8scdA (length=264) Species: 77133 (uncultured bacterium) [Search protein sequence]
GMSKIFGIVNITTDSFSDGGLYLDTDKAIEHALHLVEDGADVIDLGAASS
NPDTTEVGVVEEIKRLKPVIKALKEKGISISVDTFKPEVQSFCIEQKVDF
INDIQGFPYPEIYSGLAKSDCKLVLMHSVQRIGAATKVETNPAAVFTSMM
EFFKERIAALVEAGVKRERIILDPGMGFFLGSNPETSILVLKRFPEIQEA
FNLQVMIAVSRKSFLGKITGTDVKSRLAPTLAAEMYAYKKGADYLRTHDV
KSLSDALKISKALG
3D structure
PDB8scd Molecular mechanism of plasmid-borne resistance to sulfonamide antibiotics.
ChainA
Resolution2.06 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.15: dihydropteroate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 XHP A D82 N101 M125 D172 F178 A207 K211 R245 D83 N102 M126 D173 F179 A208 K212 R246
BS02 PAB A F15 S49 N50 G176 F177 F178 K211 S212 F16 S50 N51 G177 F178 F179 K212 S213
BS03 POP A N9 S14 F15 S48 S49 N50 R245 H247 N10 S15 F16 S49 S50 N51 R246 H248
Gene Ontology
Molecular Function
GO:0004156 dihydropteroate synthase activity
GO:0016740 transferase activity
GO:0046872 metal ion binding
Biological Process
GO:0009396 folic acid-containing compound biosynthetic process
GO:0042558 pteridine-containing compound metabolic process
GO:0044237 cellular metabolic process
GO:0046654 tetrahydrofolate biosynthetic process
GO:0046656 folic acid biosynthetic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8scd, PDBe:8scd, PDBj:8scd
PDBsum8scd
PubMed37419898
UniProtQ8GJ22

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