Structure of PDB 8sc7 Chain A

Receptor sequence
>8sc7A (length=326) Species: 9606 (Homo sapiens) [Search protein sequence]
AMGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVA
IKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLM
PFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNV
LVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTH
QSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDV
YMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPT
DSNFYRALMDEEDMDDVVDADEYLIP
3D structure
PDB8sc7 Structure of EGFR in complex with MTX-531
ChainA
Resolution1.984 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 D0D A L718 A743 K745 L788 T790 Q791 L792 M793 G796 C797 D800 L844 L25 A50 K52 L95 T97 Q98 L99 M100 G103 C104 D107 L151
External links
PDB RCSB:8sc7, PDBe:8sc7, PDBj:8sc7
PDBsum8sc7
PubMed
UniProtP00533|EGFR_HUMAN Epidermal growth factor receptor (Gene Name=EGFR)

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