Structure of PDB 8sab Chain A

Receptor sequence

>8sabA (length=392) Species: 1028307 (Klebsiella aerogenes KCTC 2190)

KHLDTALVNAGRRKKYTQGSVNSVIQRASSLVFDTVEAKKHATRNRAKGE
LFYGRRGTLTHFSLQEAMCELEGGAGCALFPCGAAAVANTILAFVEQGDH
VLMTNTAYEPSQDFCTKILAKLGVTTGWFDPLIGADIANLIQPNTKVVFL
ESPGSITMEVHDVPAIVAAVRRVAPEAIIMIDNTWAAGVLFKALDFGIDI
SIQAATKYLIGHSDGMIGTAVANARCWEQLCENAYLMGQMIDADTAYMTS
RGLRTLGVRLRQHHESSLRVAEWLAQHPQVARVNHPALPGSKGHEFWKRD
FSGSSGLFSFVLNKRLTDAELAAYLDNFSLFSMAYSWGGFESLILANQPE
HIAAIRPEAEVDFSGTLIRLHIGLENVDDLLADLAAGFARIV

3D structure

• PDB: 8sab Crystal Structure of Cystathionine beta lyase from Klebsiella aerogenes, PLP adduct with Alanine (C2 form)
• Chain: A
• Resolution: 1.6 Å

Enzymatic activity

• Enzyme Commision number: 4.4.1.8: Transferred entry: 4.4.1.13.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	LYS	A	N12 R15 R16 K17 T20	N9 R12 R13 K14 T17
BS02	PP3	A	C85 G86 A87 Y111 D185 A207 T209 K210 M219 Y338 S339 W340 R372	C82 G83 A84 Y108 D182 A204 T206 K207 M216 Y335 S336 W337 R369
BS03	PLP	A	C85 G86 A87 Y111 D185 A207 T209 K210 M219 W340	C82 G83 A84 Y108 D182 A204 T206 K207 M216 W337
BS04	LYS	A	L333 E344	L330 E341

Gene Ontology

Molecular Function

• GO:0016829 lyase activity
• GO:0030170 pyridoxal phosphate binding
• GO:0046872 metal ion binding
• GO:0047804 cysteine-S-conjugate beta-lyase activity

Biological Process

• GO:0006520 amino acid metabolic process
• GO:0019346 transsulfuration
• GO:0019450 L-cysteine catabolic process to pyruvate

External links

• PDB: RCSB:8sab, PDBe:8sab, PDBj:8sab
• PDBsum: 8sab
• UniProt: A0A0H3FMF8