Structure of PDB 8s9f Chain A

Receptor sequence
>8s9fA (length=254) Species: 10090 (Mus musculus) [Search protein sequence]
YGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIREGSMSEDE
FIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRH
RFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFG
LSRYPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSE
TAEHIAQGLRLPRPHLASERVYTIMYSCWHEKADERPSFKILLSNILDVM
DEES
3D structure
PDB8s9f Crystal structure of the kinase domain of Bruton's Tyrosine Kinase bound to dasatinib
ChainA
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1N1 A L408 A428 K430 T474 E475 Y476 M477 N479 G480 L528 F540 L17 A37 K39 T83 E84 Y85 M86 N88 G89 L137 F149
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8s9f, PDBe:8s9f, PDBj:8s9f
PDBsum8s9f
PubMed38189455
UniProtP35991|BTK_MOUSE Tyrosine-protein kinase BTK (Gene Name=Btk)

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