Structure of PDB 8s9d Chain A

Receptor sequence
>8s9dA (length=368) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
ENFVPGLDGVVAFTTEIAEPDKDGGALRYRGVDIEDLVSQRVTFGDVWAL
LVDGNFGSGLPPAEPFPLPIHSGDVRVDVQAGLAMLAPIWGYAPLLDIDD
ATARQQLARASVMALSYVAQSARGIYQPAVPQRIIDESSTVTARFMTRWQ
GEPDPRHIEAIDAYWVSAAEHGMNASTFTARVIASTGADVAAALSGAIGA
MSGPLHGGAPARVLPMLDEVERAGDARSVVKGILDRGEKLMGFGHRVYRA
EDPRARVLRAAAERLGAPRYEVAVAVEQAALSELRERRPDRAIETNVEFW
AAVVLDFARVPANMMPAMFTCGRTAGWCAHILEQKRLGKLVRPSAIYVGP
GPRSPESVDGWERVLTTA
3D structure
PDB8s9d Mycobacterium tuberculosis CitA activity is modulated by cysteine oxidation and pyruvate binding.
ChainA
Resolution2.57 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.3.16: citrate synthase (unknown stereospecificity).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FLC A H176 N179 R259 R328 H171 N174 R254 R323
Gene Ontology
Molecular Function
GO:0004108 citrate (Si)-synthase activity
GO:0016740 transferase activity
GO:0036440 citrate synthase activity
GO:0046912 acyltransferase activity, acyl groups converted into alkyl on transfer
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006099 tricarboxylic acid cycle
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8s9d, PDBe:8s9d, PDBj:8s9d
PDBsum8s9d
PubMed37252106
UniProtP9WPD3|CISY2_MYCTU Putative citrate synthase 2 (Gene Name=citA)

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