Structure of PDB 8s94 Chain A

Receptor sequence
>8s94A (length=328) Species: 9606 (Homo sapiens) [Search protein sequence]
EFSLKDLYAIQEIQAEENLFKLIVNSLCPVIFGHELVKAGLALALFGGSQ
KYADDKNRIPIRGDPHILVVGDPGLGKSQMLQAACNVAPRGVYVCGNTTT
TSGLTVTAGALVLGDQGICGIDQFDKMGNQHQALLEAMEQQSISLAKAGV
VCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALLSRFDLVFILLDT
PNEHHDHLLSEHVIAIRAKPLSERLKVVPGETIDPIPHQLLRKYIGYARQ
YVYPRLSTEAARVLQDFYLELRKQSQRLNSSPITTRQLESLIRLTEARAR
LELREEATKEDAEDIVEIMKYSMLGTYS
3D structure
PDB8s94 Activity, substrate preference and structure of the HsMCM8/9 helicase.
ChainA
Resolution3.94 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A F415 G457 L458 G459 S461 L605 F32 G74 L75 G76 S78 L209
BS02 MG A S461 D518 S78 D122
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003697 single-stranded DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0017116 single-stranded DNA helicase activity
GO:0019899 enzyme binding
GO:0032406 MutLbeta complex binding
GO:0032407 MutSalpha complex binding
GO:0032408 MutSbeta complex binding
Biological Process
GO:0000724 double-strand break repair via homologous recombination
GO:0006139 nucleobase-containing compound metabolic process
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006974 DNA damage response
GO:0007292 female gamete generation
GO:0032508 DNA duplex unwinding
GO:0036298 recombinational interstrand cross-link repair
GO:0048232 male gamete generation
GO:0050821 protein stabilization
GO:0070716 mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication
GO:0071168 protein localization to chromatin
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0042555 MCM complex
GO:0097362 MCM8-MCM9 complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8s94, PDBe:8s94, PDBj:8s94
PDBsum8s94
PubMed37309874
UniProtQ9UJA3|MCM8_HUMAN DNA helicase MCM8 (Gene Name=MCM8)

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