Structure of PDB 8s93 Chain A

Receptor sequence
>8s93A (length=429) Species: 10090 (Mus musculus) [Search protein sequence]
MAAVILESIFLKRSQQKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSK
KGSIDVEKITCVETVIPEKNPPPERQIPRRGAERFPYPFQVVYDEGPLYV
FSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAM
GCQILENRGGGSGGGEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIR
MIREGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANG
CLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVN
DQGVVKVSDFGMTRYVLDDEYTSSTGSKFPVKWASPEVLMYSKFSSKSDI
WAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLPRPHLASERVYTIM
YSCWHEKADERPSFKILLSNILDVMDEES
3D structure
PDB8s93 Crystal structure of the PH-TH/kinase complex of Bruton's tyrosine kinase
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 9AJ A L408 T410 G411 Q412 F413 V416 R430 Y476 M477 A478 N479 G480 D521 N526 L528 D539 Y551 L178 T180 G181 Q182 F183 V186 R200 Y246 M247 A248 N249 G250 D291 N296 L298 D309 Y321
BS02 ZN A H143 C155 C165 H130 C142 C152
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0035556 intracellular signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:8s93, PDBe:8s93, PDBj:8s93
PDBsum8s93
PubMed38189455
UniProtP35991|BTK_MOUSE Tyrosine-protein kinase BTK (Gene Name=Btk)

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