Structure of PDB 8s65 Chain A

Receptor sequence

>8s65A (length=410) Species: 5811 (Toxoplasma gondii) [Search protein sequence]

RVKRLVVLGSTGSIGKSTLEIAREFPDIFQIVGLAAGGSNLALLAEQVAA
FRPQYVYLGDSSKVAELQERLNDHERSAAFPRPRLLLGDEGLAELACVPN
YDILVSAIVGFKGVLPTLKALEAGKDVALANKEALVAAGPVFRCLLSTRG
LLYGDQERKCGLLLPVDSEHSAIFQALQGVPASCYPPRKLLLTASGGPFR
GRTRDELEQVTLESALKHPKWSMGAKITIDSATLMNKGLEVIEAHFAFGC
PYSSIEVLVHPQAVIHSAVELRDGATLAQLGLPDMKLPIAYALTWPHRLA
APWSAGVDLTREGNLTFEKPDLNTFGCLGLAYEAGERGGVAPACLNAANE
VAVERFRNKEIGFVDIEDTVRHVMALQERERDNFSDVSLQDVFDADHWAR
TAARAFKPRK

3D structure

PDB

8s65 1-Deoxy-d-xylulose 5-phosphate reductoisomerase as target for anti Toxoplasma gondii agents: crystal structure, biochemical characterization and biological evaluation of inhibitors.

Chain

Resolution

2.56 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	NAP	A	G33 T35 G36 S37 I38 A60 G61 S63 Y81 I132 A154 E157 D229 M285 G286 I289 M347	G9 T11 G12 S13 I14 A36 G37 S39 Y57 I108 A130 E133 D167 M223 G224 I227 M285
BS02	FOM	A	S230 E231 S257 H280 W283 S293 N298 K299	S168 E169 S195 H218 W221 S231 N236 K237
BS03	MG	A	I55 F75 R76	I31 F51 R52
BS04	MG	A	G36 I38 A131	G12 I14 A107

External links

PDB	RCSB:8s65, PDBe:8s65, PDBj:8s65
PDBsum	8s65
PubMed	39105673
UniProt	S8ESX0

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