Structure of PDB 8s31 Chain A

Receptor sequence
>8s31A (length=227) Species: 9606 (Homo sapiens) [Search protein sequence]
EVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDY
SDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSS
HPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRT
RSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLL
EEYGCCKELASRLRYARTMVDKLLSSR
3D structure
PDB8s31 PLK1-mediated phosphorylation cascade activates Mis18 complex to ensure centromere inheritance.
ChainA
Resolution2.134 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A W414 V415 D416 E488 H489 L490 L491 R516 H538 K540 W47 V48 D49 E121 H122 L123 L124 R149 H171 K173
External links
PDB RCSB:8s31, PDBe:8s31, PDBj:8s31
PDBsum8s31
PubMed39236175
UniProtP53350|PLK1_HUMAN Serine/threonine-protein kinase PLK1 (Gene Name=PLK1)

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