Structure of PDB 8s0s Chain A

Receptor sequence
>8s0sA (length=494) Species: 9606 (Homo sapiens) [Search protein sequence]
RRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTH
IKIQNTGDYYDLYGGEKFATLAELVQYYMEHQLKEGDVIELKYPLNCADP
TSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDD
GKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQL
KQPLNTTRINAAEIESRVRELSKQGFWEEFETLQQQECKLLYSRKEGQRQ
ENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEKKSYIATQ
GCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYG
VMRVRNVKESAAHDYTLRELKLSKVGQTERTVWQYHFRTWPDHGVPSDPG
GVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKG
VDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQR
3D structure
PDB8s0s Fragment-Based Discovery of Allosteric Inhibitors of SH2 Domain-Containing Protein Tyrosine Phosphatase-2 (SHP2).
ChainA
Resolution1.94 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A1H4H A E110 R111 F113 H114 T218 T219 E250 T253 L254 P491 E103 R104 F106 H107 T206 T207 E229 T232 L233 P458
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8s0s, PDBe:8s0s, PDBj:8s0s
PDBsum8s0s
PubMed38462716
UniProtQ06124|PTN11_HUMAN Tyrosine-protein phosphatase non-receptor type 11 (Gene Name=PTPN11)

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