Structure of PDB 8ru4 Chain A

Receptor sequence
>8ru4A (length=504) Species: 9606 (Homo sapiens) [Search protein sequence]
AIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRT
MQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSV
LFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCL
QILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCS
SNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGL
LGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTV
LRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPP
SHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRF
VEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENI
QRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLF
RMSE
3D structure
PDB8ru4 Structure-Based Design of Bicyclic Helical Peptides That Target the Oncogene beta-Catenin.
ChainA
Resolution2.13 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A H219 F253 T257 H260 N261 K292 I296 D299 K335 H68 F102 T106 H109 N110 K141 I145 D148 K184
BS02 GLC A K345 W383 R386 N387 K194 W232 R235 N236
BS03 GLC A K270 Q302 Y306 K119 Q151 Y155
External links
PDB RCSB:8ru4, PDBe:8ru4, PDBj:8ru4
PDBsum8ru4
PubMed39167026
UniProtP35222|CTNB1_HUMAN Catenin beta-1 (Gene Name=CTNNB1)

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