Structure of PDB 8rqf Chain A

Receptor sequence
>8rqfA (length=301) Species: 9606 (Homo sapiens) [Search protein sequence]
NFTLPPNFGKRPTDLALSVILVFMLFFIMLSLGCTMEFSKIKAHLWKPKG
LAIALVAQYGIMPLTAFVLGKVFRLKNIEALAILVCGCSPGGNLSNVFSL
AMKGDMNLSIVMTTCSTFCALGMMPLLLYIYSRGIYDGDLKDKVPYKGIV
ISLVLVLIPCTIGIVLKSKRPQYMRYVIKGGMIIILLCSVAVTVLSAINV
GKSIMFAMTPLLIATSSLMPFIGFLLGYVLSALFCLNGRCRRTVSMETGC
QNVQLCSTILNVAFPPEVIGPLFFFPLLYMIFQLGEGLLLIAIFWCYEKF
K
3D structure
PDB8rqf Cryo-EM structure of human NTCP-Bulevirtide complex
ChainA
Resolution3.41 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BJU A D152 Y156 D142 Y146
Gene Ontology
Molecular Function
GO:0001618 virus receptor activity
GO:0005515 protein binding
GO:0008508 bile acid:sodium symporter activity
GO:0015125 bile acid transmembrane transporter activity
GO:0015293 symporter activity
Biological Process
GO:0006814 sodium ion transport
GO:0006869 lipid transport
GO:0014070 response to organic cyclic compound
GO:0015721 bile acid and bile salt transport
GO:0031667 response to nutrient levels
GO:0043627 response to estrogen
GO:0045471 response to ethanol
GO:0046718 symbiont entry into host cell
GO:0055085 transmembrane transport
GO:0071466 cellular response to xenobiotic stimulus
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016323 basolateral plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8rqf, PDBe:8rqf, PDBj:8rqf
PDBsum8rqf
PubMed
UniProtQ14973|NTCP_HUMAN Hepatic sodium/bile acid cotransporter (Gene Name=SLC10A1)

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