Structure of PDB 8rqc Chain A

Receptor sequence

>8rqcA (length=300) Species: 9606 (Homo sapiens) [Search protein sequence]

MEEFRTLHDDDSIQVIPVLPQVMMILVPGQTLPLQLFHPQEVSMVRNLIQ
NDRTFAVLAYSNVQEAEFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKV
LELRTQSDGIQQAKVQILPEGSGDAETLMDRIKKQLREWDENLKDDSLPS
NPIDFSYWVAANLPIDDSLRIQLLKIDSAIQRLRCELDIMNKCTSLCCKQ
CQETEITTKNEIFSLSREGPMAAYVNPHGYVHEILTVYKACNLNLIGRPS
TEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALIPT

3D structure

PDB

8rqc Design of a Cereblon construct for crystallographic and biophysical studies of protein degraders

Chain

Resolution

2.15 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	A	Q325 N351 H353 Y355 I371 W386 V388 H397 W400	Q200 N226 H228 Y230 I246 W261 V263 H272 W275
BS02	peptide	A	C326 Q327 E328	C201 Q202 E203
BS03	ZN	A	C323 C326 C391 C394	C198 C201 C266 C269
BS04	QFC	A	F102 N351 P352 H353 E377 H378 S379 W380 W386 W400 F402	F37 N226 P227 H228 E252 H253 S254 W255 W261 W275 F277

External links

PDB	RCSB:8rqc, PDBe:8rqc, PDBj:8rqc
PDBsum	8rqc
PubMed
UniProt	Q96SW2\|CRBN_HUMAN Protein cereblon (Gene Name=CRBN)

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