Structure of PDB 8rq9 Chain A

Receptor sequence

>8rq9A (length=316) Species: 9606 (Homo sapiens) [Search protein sequence]

PNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSIQVIPVLPQVMMILVP
GQTLPLQLFHPQEVSMVRNLIQNDRTFAVLAYSNVQEREAEFGTTAEIYA
YREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPEAETLMD
RIKKQLREWDEDSLPSNPIDFSYWVAANLPIDDSLRIQLLKIDSAIQRLR
CELDIMNKCTSLCCKQCQETEITTKNEIFSLSREGPMAAYVNPHGYVHEI
LTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDM
SPQKFWGLTRSALIPT

3D structure

PDB

8rq9 Design of a Cereblon construct for crystallographic and biophysical studies of protein degraders

Chain

Resolution

2.91 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	A1H2F	A	H378 W380 W386 F402	H269 W271 W277 F293
BS02	ZN	A	C323 C391 C394	C214 C282 C285

External links

PDB	RCSB:8rq9, PDBe:8rq9, PDBj:8rq9
PDBsum	8rq9
PubMed
UniProt	Q96SW2\|CRBN_HUMAN Protein cereblon (Gene Name=CRBN)

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