Structure of PDB 8rox Chain A

Receptor sequence
>8roxA (length=322) Species: 9606 (Homo sapiens) [Search protein sequence]
HVLKQLERVKISGQLSPRLFRKLPPRVCVSLKNIVDEDAGHIFLGFSKCG
RYVLSYTSSFYIYHLYWWEFNVHSKLKLVRQVRLFQDEEIYSDLYLTVCE
WPSDASKVIVFGFNTENHRDIYVSTVAVPPPDPNAQCLRHGFMLHTKYQV
VYPFPTFQPAFQLKKDQVVLLNTSYSLVACAVSVHSFCQILVVTDLRGRN
LRPMRQYLTVEQLTLDFEYVINEVIRHDATWGHQFCSFSDYDIVILEVCP
ETNQVLINIGLLPKTYHTSLKVAWDLNTFETVSVGDLTSGSVWSSYRKSC
VDMVMKWLVPESSGRYVNRMTN
3D structure
PDB8rox Optimization of Potent Ligands for the E3 Ligase DCAF15 and Evaluation of Their Use in Heterobifunctional Degraders.
ChainA
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A1H17 A T230 Q232 A234 F235 T156 Q158 A160 F161
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0036094 small molecule binding
GO:0046872 metal ion binding
Biological Process
GO:0000209 protein polyubiquitination
GO:0002376 immune system process
GO:0016567 protein ubiquitination
GO:0032814 regulation of natural killer cell activation
Cellular Component
GO:0080008 Cul4-RING E3 ubiquitin ligase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8rox, PDBe:8rox, PDBj:8rox
PDBsum8rox
PubMed38513086
UniProtQ66K64|DCA15_HUMAN DDB1- and CUL4-associated factor 15 (Gene Name=DCAF15)

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