Structure of PDB 8rog Chain A

Receptor sequence
>8rogA (length=359) Species: 9606 (Homo sapiens) [Search protein sequence]
GFLKLIEIENFKSYKGRQIIGPFQRFTAIIGPNGSGKSNLMDAISFVLGE
KTSNLRVKTLRDLIHGAPVGKPAANRAFVSMVYSEEGAEDRTFARVIVGG
SSEYKINNKVVQLHEYSEELEKLGILIKARNFLVFQGAVESIAMKNPKER
TALFEEISRSGELAQEYDKRKKEMGSGSLVPRGSGSAKQAFEQIKKERFD
RFNACFESVATNIDEIYKALSRNSSAQAFLGPENPEEPYLDGINYNCVAP
GKRFRPMDNLSGGEKTVAALALLFAIHSYKPAPFFVLDQIDAALDNTNIG
KVANYIKEQSTCNFQAIVISLKEEFYTKAESLIGVYPEQGDCVISKVLTF
DLTKYPDAN
3D structure
PDB8rog The cohesin ATPase cycle is mediated by specific conformational dynamics and interface plasticity of SMC1A and SMC3 ATPase domains.
ChainA
Resolution1.94 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A S39 Q137 S38 Q136
BS02 AGS A K13 N34 G35 G37 K38 S39 N40 R57 I65 H66 P69 V1211 K12 N33 G34 G36 K37 S38 N39 R56 I64 H65 P68 V343
External links
PDB RCSB:8rog, PDBe:8rog, PDBj:8rog
PDBsum8rog
PubMed39240714
UniProtQ14683|SMC1A_HUMAN Structural maintenance of chromosomes protein 1A (Gene Name=SMC1A)

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