Structure of PDB 8rn7 Chain A

Receptor sequence

>8rn7A (length=518) Species: 1601067 (Influenza B virus (B/Memphis/13/2003)) [Search protein sequence]

GIDFKLGQTISRLRDISVPAGFSNFEGMRSYIDNIDPKGAIERNLARMSP
LVSVTPKKLTWEDLRPIGPHIYNHELPEVPYNAFLLMSDELGLANMTEGK
SKKPKTLAKECLEKYSTLRDQTDPILIMKSEKANENFLWKLWRDCVNTIS
NEEMSNELQKTNYAKWATGDGLTYQKIMKEVAIDDETMCQEEPKIPNKCR
VAAWVQTEMNLLSTLTSKRALDLPEIGPDVAPVEHVGSERRKYFVNEINY
CKASTVMMKYVLFHTSLLNESNASMGKYKVIPITNRVVNEKGESFDMLYG
LAVKGQSHLRGDTDVVTVVTFEFSSTDPRVDSGKWPKYTVFRIGSLFVSG
REKSVYLYCRVNGTNKIQMKWGMEARRCLLQSMQQMEAIVEQESSIQGYD
MTKACFKGDRVNSPKTFSIGTQEGKLVKGSFGKALRVIFTKCLMHYVFGN
AQLEGFSAESRRLLLLIQALKDRKGPWVFDLEGMYSGIEECISNNPWVIQ
SAYWFNEWLGFEKEGSKV

3D structure

PDB

8rn7 Structures of influenza A and B replication complexes give insight into avian to human host adaptation and reveal a role of ANP32 as an electrostatic chaperone for the apo-polymerase.

Chain

Resolution

3.09 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	W364 L370	W166 L172
BS02	peptide	A	N332 N334 F335 N360 Y361 W364 Q373 I375 M376 V379 D382	N134 N136 F137 N162 Y163 W166 Q175 I177 M178 V181 D184

External links

PDB	RCSB:8rn7, PDBe:8rn7, PDBj:8rn7
PDBsum	8rn7
PubMed	39160148
UniProt	Q5V8Z9

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