Structure of PDB 8ri2 Chain A

Receptor sequence
>8ri2A (length=486) Species: 9606 (Homo sapiens) [Search protein sequence]
KDYRKKYRKYVRSRFQCIEDLNKRYTRLRLIKEHPIKMELLFDPDDEHSE
PVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLV
TQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGP
LCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRH
VEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWI
VCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQCAHLWGLCSLAADGI
WNQKILFEESDLRNHGLQKADVSAFLRMNLFQKCEKFYSFIHMTFQEFFA
AMYYLLEEELPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLE
KKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFV
QRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESL
3D structure
PDB8ri2 Discovery of Potent, Orally Bioavailable, Tricyclic NLRP3 Inhibitors.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A1H02 A A227 A228 I411 T439 Y443 F575 R578 Q624 E629 Y632 M661 A60 A61 I244 T272 Y276 F382 R385 Q431 E436 Y439 M468
BS02 ADP A Y168 T169 L171 G229 G231 K232 T233 I234 Y381 P412 H522 Y25 T26 L28 G62 G64 K65 T66 I67 Y214 P245 H342
External links
PDB RCSB:8ri2, PDBe:8ri2, PDBj:8ri2
PDBsum8ri2
PubMed38175811
UniProtQ96P20|NLRP3_HUMAN NACHT, LRR and PYD domains-containing protein 3 (Gene Name=NLRP3)

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