Structure of PDB 8rhg Chain A

Receptor sequence

>8rhgA (length=330) Species: 9606 (Homo sapiens) [Search protein sequence]

QLLRIDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRH
YWKDERLSFPSTNNLSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNV
MLRVQPDGKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEIESYAYTEDDL
MLYWKKGNDSLKTDERISLSQFLIQEFHTTTKLAFYSSTGWYNRLYINFT
LRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLTMST
IITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKE
QDTHAIDKYSRIIFPAAYILFNLIYWSIFS

3D structure

PDB

8rhg Divergent mechanisms of steroid inhibition in the human rho1 GABAA receptor

Chain

Resolution

3.01 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ABU	A	Y219 T265	Y143 T189
BS02	A8W	A	P315 T319	P239 T243

External links

PDB	RCSB:8rhg, PDBe:8rhg, PDBj:8rhg
PDBsum	8rhg
PubMed
UniProt	P24046\|GBRR1_HUMAN Gamma-aminobutyric acid receptor subunit rho-1 (Gene Name=GABRR1)

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