Structure of PDB 8re2 Chain A

Receptor sequence

>8re2A (length=442) Species: 1299 (Deinococcus radiodurans)

KIDLDLDDIQATVLRERPEPYYGTHAMVRFDTAEGGRELLKRLLPHIASA
EKWWDVKYAWTAAAISYEGLKKLGVPQDSLDSFPESFKVGMAGRAEHLFD
VGENDPKHWEKPFGTGQVHLALTIFAENEENWQKALVIAEHELEATKGVT
LLMREDFGAQPDSRNSLGYKDMISNPAIEGSGIKPFPGQGPAIKPGEFVL
GYPGEAGVPLGMPKPEVLGKNGTFVALRKYHTNAGSFNRYLKENAEYTGG
DAELLAAKLVGRWRSGAPLTLAPKEDDPELGHDPNRNNDFTYKNDPEGLE
VPLGSHIRRMNPRDTKLELLTDVNIHRIIRRATAYGPAYDPKADSLAEDK
VERGLYFIFISAKAMDTTEFLQKEWINKANFIGQGSERDPIVGLQDEDLT
FTLPKEPVRQRLRGMDTFNVLRGGEYLFMPSLSALKWLSELK

3D structure

• PDB: 8re2 Biochemical, Biophysical, and Structural Analysis of an Unusual DyP from the Extremophile Deinococcus radiodurans.
• Chain: A
• Resolution: 2.2 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	HEM	A	M190 I191 S192 Y248 R280 H324 I325 M328 N329 R331 R348 L373 F375 F377 L389 I409 V410 N437	M172 I173 S174 Y230 R262 H306 I307 M310 N311 R313 R330 L355 F357 F359 L371 I391 V392 N419
BS02	MG	A	Q28 A29 T30 A80	Q10 A11 T12 A62
BS03	MG	A	Y357 D358 E366 R371	Y339 D340 E348 R353
BS04	MG	A	H249 Y353 E370	H231 Y335 E352

Gene Ontology

Molecular Function

• GO:0004601 peroxidase activity
• GO:0020037 heme binding
• GO:0046872 metal ion binding

Biological Process

• GO:0098869 cellular oxidant detoxification

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:8re2, PDBe:8re2, PDBj:8re2
• PDBsum: 8re2
• PubMed: 38257271
• UniProt: Q9RZ08