Structure of PDB 8rbx Chain A

Receptor sequence
>8rbxA (length=1391) Species: 9823 (Sus scrofa) [Search protein sequence]
SACPLRTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGRPKLGGLMDP
RQGVIERTGRCQTCAGNMTECPGHFGHIELAKPVFHVGFLVKTMKVLRCV
CFFCSKLLVDSNNPKIKDILAKSKGQPKKRLTHVYDLCKKNICGGCGRYQ
PRIRRSGLELYAEWKKKILLSPERVHEIFKRISDEECFVLGMEPRYARPE
WMIVTVLPVPPLSVRPAVRNQDDLTHKLADIVKINNQLRRNEQNGAAAHV
IAEDVKLLQFHVATMVDNELPGLPRAMQKSGRPLKSLKQRLKGKEGRVRG
NLMGKRVDFSARTVITPDPNLSIDQVGVPRSIAANMTFAEIVTPFNIDRL
QELVRRGNSQYPGAKYIIRDNGDRIDLRFHPKPSDLHLQTGYKVERHMCD
GDIVIFNRQPTLHKMSMMGHRVRILPWSTFRLNLSVTTPYNADFDGDEMN
LHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQDTLTAVRKFTKRD
VFLERGEVMNLLMFLSTWDGKVPQPAILKPRPLWTGKQIFSLIIPGHINC
IRTHSTHPDDEDSGPYKHISPGDTKVVVENGELIMGILCKKSLGTSAGSL
VHISYLEMGHDITRLFYSNIQTVINNWLLIEGHTIGIGDSIADSKTYQDI
QNTIKKAKQDVIEVIEKAHNNELEPTPGNTLRQTFENQVNRILNDARDKT
GSSAQKSLSEYNNFKSMVVSGAKGSKINISQVIAVVGQQNVEGKRIPFGF
KHRTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFFHAMGGREGLIDTAV
KTAETGYIQRRLIKSMESVMVKYDATVRNSINQVVQLRYGEDGLAGESVE
FQNLATLKPSNKAFEKKFRFDYTNERALRRTLQEDLVKDVLSNAHIQNEL
EREFERMREDREVLRVIFPTGDSKVVLPCNLLRMIWNAQKIFHINPRLPS
DLHPIKVVEGVKELSKKLVIVNGDDPLSRQAQENATLLFNIHLRSTLCSR
RMAEEFRLSGEAFDWLLGEIESKFNQAIAHPGEMVGALAAQSLGEPATQM
VTLGVPRLKELINISKKPKTPSLTVFLLGQSARDAERAKDILCRLEHTTL
RKVTANTAIYYDPNPQSTVVAEDQEWVNVISPWLLRVELDRKHMTDRKLT
MEQIAEKINAGFGDDLNCIFNDDNAEKLVLRIRIMNDDDVFLRCIESNML
TDMTLQGIEQISKVYMHLPQTDNKKKIIITEDGEFKALQEWILETDGVSL
MRVLSEKDVDPVRTTSNDIVEIFTVLGIEAVRKALERELYHVISFDGSYV
NYRHLALLCDTMTCRGHLMAITRHGVNRQDTGPLMKCSFEETVDVLMEAA
AHGESDPMKGVSENIMLGQLAPAGTGCFDLLLDAEKCKYGM
3D structure
PDB8rbx Structural basis of Integrator-dependent RNA polymerase II termination
ChainA
Resolution4.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A R67 R430 F431 Q461 D497 D499 R57 R378 F379 Q409 D445 D447
BS02 dna A N272 S332 K340 K346 R351 R358 R364 Q461 A855 Y859 R1416 E1433 D1437 N220 S280 K288 K294 R299 R306 R312 Q409 A803 Y807 R1323 E1340 D1344
BS03 ZN A C111 C114 C101 C104
BS04 ZN A C71 C81 H84 C61 C71 H74
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0031981 nuclear lumen
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8rbx, PDBe:8rbx, PDBj:8rbx
PDBsum8rbx
PubMed38570683
UniProtA0A7M4DUC2

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