Structure of PDB 8r8d Chain A

Receptor sequence
>8r8dA (length=224) Species: 9606 (Homo sapiens) [Search protein sequence]
VVGGLVALRGAHPYIAALYWGHSFCAGSLIAPCWVLTAAHCLQDRPAPED
LTVVLGQERRNHSCEPCQTLAVRSYRLHEAFSPVSYQHDLALLRLQEDAD
GSCALLSPYVQPVSLPLCQVAGWGHQFEGAEEYASFLQEAQVPFLSLERC
SAPDVHGSSILPGMLCAGFLEGGTDACQGDSGGPLVCLTLQGIISWGSGC
GDRNKPGVYTDVAYYLAWIREHTV
3D structure
PDB8r8d Structural basis for inhibition of beta-FXIIa by garadacimab
ChainA
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.38: coagulation factor XIIa.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FUC A G38 H39 G21 H22
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:8r8d, PDBe:8r8d, PDBj:8r8d
PDBsum8r8d
PubMed39059382
UniProtP00748|FA12_HUMAN Coagulation factor XII (Gene Name=F12)

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