Structure of PDB 8r65 Chain A

Receptor sequence

>8r65A (length=716) Species: 88776 (Influenza A virus (A/Brevig Mission/1/1918(H1N1))) [Search protein sequence]

MEDFVRQCFNPMIVELAEKAMKEYGEDLKIETNKFAAICTHLEVCFMYSD
FHFINERGESIIVESGDPNALLKHRFEIIEGRDRTMAWTVVNSICNTTGA
EKPKFLPALYDYKENRFIEIGVTRREVHIYYLEKANKIKSEKTHIHIFSF
TGEEMATKADYTLDEESRARIKTRLFTIRQEMASRGLWDSFRQSERGEET
IEERFEITGTMRRLADQSLPPNFSSLENFRAYVDGFEPNGYIEGKLSQMS
KEVNARIEPFLKTTPRPLRLPDGPPCSQRSKFLLMDALKLSIEDPSHEGE
GIPLYDAIKCMRTFFGWKEPNVVKPHEKGINPNYLLAWKQVLAELQDIEN
EEKIPKTKNMKKTSQLKWALGENMAPEKVDFDDCKDVSDLKQYDSDEPEL
RSLASWIQSEFNKACELTDSSWIELDEIGEDVAPIEHIASMRRNYFTAEV
SHCRATEYIMKGVYINTALLNASCAAMDDFQLIPMISKCRTKEGRRKTNL
YGFIIKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKYCVLEIGDMLL
RSAIGQVSRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAES
SVKEKDMTKEFFENKSETWPIGESPKGVEEGSIGKVCRTLLAKSVFNSLY
ASPQLEGFSAESRKLLLIVQALRDNLEPGTFDLGGLYEAIEECLINDPWV
LLNASWFNSFLTHALR

3D structure

PDB

8r65 1918 H1N1 Viral polymerase heterotrimer in complex with 4 repeat serine-5 phosphorylated PolII peptide with ordered PB2 C-terminal domains

Chain

Resolution

4.23 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

3.1.-.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	A	H326 K328 G371 E372 N373 M374 A375 Y393 E397 H510 R512 V517 K539 R566 N568 G569 K574 P653	H326 K328 G371 E372 N373 M374 A375 Y393 E397 H510 R512 V517 K539 R566 N568 G569 K574 P653
BS02	rna	A	M477 L511 R512	M477 L511 R512
BS03	peptide	A	A287 L288 K289 L290 S291 T313 L417 Y445 A448 E449 R454 M548 L549 L550 R551 S552 R559 F612 E613 K635	A287 L288 K289 L290 S291 T313 L417 Y445 A448 E449 R454 M548 L549 L550 R551 S552 R559 F612 E613 K635

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0004519	endonuclease activity
GO:0046872	metal ion binding

	Biological Process
GO:0006351	DNA-templated transcription
GO:0039523	symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694	viral RNA genome replication
GO:0075523	viral translational frameshifting
GO:0075526	cap snatching

	Cellular Component
GO:0030430	host cell cytoplasm
GO:0042025	host cell nucleus

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:8r65, PDBe:8r65, PDBj:8r65
PDBsum	8r65
PubMed
UniProt	Q3HM39\|PA_I18A0 Polymerase acidic protein (Gene Name=PA)

[Back to BioLiP]