Structure of PDB 8r3o Chain A

Receptor sequence
>8r3oA (length=664) Species: 727 (Haemophilus influenzae) [Search protein sequence]
ATRRQLANAIRVLAMDSVQKAKSGHPGAPMGMADIAEVLWRDFLKHNPTN
PKWADRDRFVLSNGHGSMLIYSLLHLTGYDLSIEDLKQFRQLHSKTPGHP
EYGYAPGVETTTGPLGQGITNAVGMAIAEKTLAGQFNREGHEIVDHHTYV
FLGDGCLMEGISHEACSLAGTLGLGKLIAFYDDNNISIDGHVDGWFSDDT
AERFEAYGWQVIRNVDGHDAEQIRAATILAQAEKGKPTLIICKTIIGFGS
PNKSGSHDSHGAPLGDEEIDLTRKALGWEYAPFEIPAEYYAEWSAKEKGA
AAEKSWEEKFAAYAKAYPELAAEFKRRVSGELPTNWAAESKAFIEKLQAN
PASIASRKASQNAIEAYAHVLPEFLGGSADLASSNLTLWSGSKPIRAHEN
VGGNYINYGVREFGMSAIMNGIALHGGFIPYGATFLMFYEYAHNAVRMAA
LMKQRTLFVYTHDSIGLGEDGPTHQPVEQTASLRLIPNLETWRPCDQVES
AIAWQQAVERQDGPSALIFTRQNLAQMDRTSAQLDAVKRGAYVLKDCDGT
PELIFIATGSEVELAVQAAEALSAEGKKVRVVSMPSTNRFDKQDAAYRES
VLPAAVTKRVAIEAGIADFWYKYVGFNGRVIGMNSFGESAPADQLFKLFG
FTVENVVAKAKEIL
3D structure
PDB8r3o Are Transketolases relevant Targets fighting Human Pathogens? A comparative Biochemical, Bioinformatic and Structural Study
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.2.1.1: transketolase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TPP A H66 L116 D155 G156 N185 I187 I189 I247 H261 H65 L115 D154 G155 N184 I186 I188 I246 H260
BS02 MG A D155 N185 I187 D154 N184 I186
BS03 TPP A D381 E413 F439 Y442 D380 E412 F438 Y441
Gene Ontology
Molecular Function
GO:0004802 transketolase activity
GO:0016740 transferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006098 pentose-phosphate shunt
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8r3o, PDBe:8r3o, PDBj:8r3o
PDBsum8r3o
PubMed
UniProtP43757|TKT_HAEIN Transketolase (Gene Name=tktA)

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