Structure of PDB 8r36 Chain A

Receptor sequence
>8r36A (length=254) Species: 10116 (Rattus norvegicus) [Search protein sequence]
NRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFLYD
VKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFS
KPFMTLGISILYRKGTPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKIS
TYEKMWAFMSSRQQSALVKNSDEGIQRVLTTDYALLMESTSIEYVTQRNC
NLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWR
GNGC
3D structure
PDB8r36 Crystal structure of the GluK1 ligand-binding domain with kainate and the full-spanning positive allosteric modulator BPAM538.
ChainA
Resolution1.9 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 KAI A E441 Y489 P516 T518 R523 G688 S689 T690 E738 E11 Y59 P86 T88 R93 G138 S139 T140 E188
BS02 9TE A K531 P532 F533 M534 T535 S761 K762 L783 Q786 K101 P102 F103 M104 T105 S211 K212 L233 Q236
External links
PDB RCSB:8r36, PDBe:8r36, PDBj:8r36
PDBsum8r36
PubMed39079583
UniProtP22756|GRIK1_RAT Glutamate receptor ionotropic, kainate 1 (Gene Name=Grik1)

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